You'll lose resolution with MIDI's 7bit "bandwidth" which could improve if sending as 14bit (2xCC).
I guess it'll depend on what you're trying to control and at what rates.
Audio would be the best for that, no doubt about it.
I'm seeing this again: VM 2.2.3 Settings AudioMIDI.PNG
Meaning, if there's enough audio in and out ports (>3 + >3) and enough MIDI ports (>2) we fortunately get at least 4 lines height on the in/out audio ports but only 2 ...